Treatment and peri-operative prophylaxis of bleeding in patients with congenital fibrinogen deficiency. In acquired hypofibrinogenemia due to major surgery or trauma, many Canadian centres use fibrinogen concentrate within protocol as part of goal-directed bleeding management.

Known hypersensitivity to the product. Avoid use if there is uncontrolled disseminated intravascular coagulation unless directed by a specialist team. 

Yes, where your local protocol incorporates fibrinogen concentrate guided by Clauss fibrinogen or viscoelastic testing. Follow local MHP sequencing. 

According to current Ontario recommendations, fibrinogen concentrate should be issued as soon as lab results indicate a need, and it is often included in the third cooler of the MHP pack.  

Many centres prefer fibrinogen concentrate for rapid, standardized dosing, small volume, no need for thawing, and reduced transfusion reactions. Use what your local protocol specifies.

Yes when indicated for hypofibrinogenemia in obstetric hemorrhage within protocol. Coordinate with obstetrics, anesthesia, and transfusion medicine. 

Yes for congenital deficiency. For acquired indications in children, follow local specialist guidance. 

To read clinical studies behind pediatric use, follow the monograph. 

No routine correction. Coagulation in liver disease is rebalanced. Treat only for active bleeding or procedures with specialist advice.