Restore fibrinogen to a functional target that supports clot formation. Typical targets are at least 1.5 g per litre for major bleeding or invasive procedures, and at least 1.0 g per litre for lesser-risk situations, aligned with local policy.

Use: 
Dose in grams = [Target g per L − Measured g per L] × Plasma volume factor 
A practical bedside rule: 1 g of fibrinogen raises Clauss fibrinogen by about 0.25 g per L in a 70 kg adult. That is approximately 0.0036 g per kg per mg per dL increment. Many sites use 50 to 70 mg per kg for major bleeding when baseline is unknown. 

Use your site’s protocol. Example starting doses for major bleeding or urgent surgery: 

If your site uses ROTEM, a common trigger is FIBTEM A20 at or below 12 mm for significant bleeding. Set a post-dose goal per local protocol, often above 12 to 14 mm.

Re-check Clauss fibrinogen about 10 to 20 minutes after infusion completion or repeat viscoelastic testing at the next cycle. Base re-dosing on laboratory recovery and clinical hemostasis.

If the target is not reached or bleeding persists, give an additional 25 to 50 mg per kg, adjusted to lab results and ongoing blood loss. Avoid unbounded cumulative dosing. Follow your site’s maximum planned cumulative dose.

A 75 kg patient with Clauss 0.9 g per L, target 1.5 g per L. Difference 0.6 g per L. Using the 1 Can you provide a worked example with a known baseline? g raises 0.25 g per L rule, estimated requirement is about 2.4 g. Round to 2.5 g and re-check labs.

Initial 50 to 70 mg per kg, then maintenance to sustain above the target per local specialist direction.

Estimate how many units of cryoprecipitate you would have used, then convert to grams. One pooled adult dose of cryo in many Canadian centres delivers roughly 2 to 4 g of fibrinogen depending on preparation. If your usual approach was “two pools of cryo for major bleeding” you likely gave about 4 to 8 g total. Start Fibryga at 50 to 70 mg per kg or dose to deliver a similar gram amount, then re-check fibrinogen and adjust. This aligns practice while you transition to concentrate-based protocols.